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Q: Which of the following drug follows zero order kinetics for metabolism?
  • A. Valproic acid
  • B. Phenytoin
  • C. Cetirizine
  • D. Loratadine
Correct Answer: Option B - Phenytoin follows nonlinear (or zero order) kinetics at therapeutic concentrations, because the rate of metabolism is close to the maximum capacity of the enzymes involved
B. Phenytoin follows nonlinear (or zero order) kinetics at therapeutic concentrations, because the rate of metabolism is close to the maximum capacity of the enzymes involved

Explanations:

Phenytoin follows nonlinear (or zero order) kinetics at therapeutic concentrations, because the rate of metabolism is close to the maximum capacity of the enzymes involved