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Q: Ondansetron acts on
  • A. 5HT₃ receptor
  • B. H1 receptor
  • C. D₂ receptor
  • D. NK1 receptor
Correct Answer: Option A - Ondansetron, a potent and highly selective 5- HT3 receptor antagonist, prevents emesis following chemotherapy by antagonising the action of 5- hydroxytryptamine (5-HT) at 5- HT3 receptors on vagal afferent neurons that innervate the gastrointestinal tract and 5- HT3 receptors in the central vomiting system.
A. Ondansetron, a potent and highly selective 5- HT3 receptor antagonist, prevents emesis following chemotherapy by antagonising the action of 5- hydroxytryptamine (5-HT) at 5- HT3 receptors on vagal afferent neurons that innervate the gastrointestinal tract and 5- HT3 receptors in the central vomiting system.

Explanations:

Ondansetron, a potent and highly selective 5- HT3 receptor antagonist, prevents emesis following chemotherapy by antagonising the action of 5- hydroxytryptamine (5-HT) at 5- HT3 receptors on vagal afferent neurons that innervate the gastrointestinal tract and 5- HT3 receptors in the central vomiting system.